Itsn1-s
WebAlthough overexpression of ITSN1-S or ITSN1-L results in oncogenic transformation of rodent fibroblasts (69, 75), evidence is lacking for a role for ITSNs in human tumorigenesis. However, the ability of ITSN1 to regulate Ras, JNK, and Cdc42 signaling provides multiple points through which ITSN1 overexpression might contribute to cellular transformation ( … Web19 feb. 2013 · Indeed, Hunter and colleagues demonstrated that overexpression of ITSN1-S in the forebrains of mice, particularly the striatum, resulted in sex-dependent decrease in locomotor activity in the transgenic animals . The level of ITSN1-S overexpression in the transgenic brains was comparable to the level of ITSN1-S observed in human DS patients.
Itsn1-s
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Web27 apr. 2024 · Besides its well-established role in endocytosis, ITSN1-s is involved in the regulation of cell signaling and is implicated in tumorigenesis processes, although the … Web28 sep. 2024 · Intersectin 1 (ITSN1) contains two isoforms: ITSN1-S and ITSN1-L, which are highly regulated by alternative splicing. Our previous results showed that the two …
Web2 aug. 2008 · ITSN1 contains many motifs involved in protein–protein interactions including two Eps15 homology (EH) domains, five consecutive Src homology 3 (SH3) domains (SH3A–E) and a proline-rich domain. In addition, ITSN1-L contains a carboxy terminus which harbors Db1 homology (DH) and pleckstrin homology (PH) domains. Web杨超，王重庆，陈颖，田巍，朱驹 （第二军医大学药学院药物化学教研室，上海 200433） 黏着斑激酶及其小分子抑制剂作为抗肿瘤药物的研究进展
Web10 sep. 2010 · Intersectin1 (also called ITSN1) as a molecular linker in the central nervous system is well known as an important regulator of endocytosis and exocytosis. ITSN1 has two isoforms: ITSN1-l and ITSN1-s. In this study, we show that siRNA-mediated down regulation of ITSN1-s induced glioma cells apoptosis. Web21 mrt. 2024 · ITSN1 (Intersectin 1) is a Protein Coding gene. Diseases associated with ITSN1 include Autosomal Dominant Non-Syndromic Intellectual Disability and …
WebVGLUT1 and dynamin bind to SH3 domains of either endophilin (Enph) or intersectin 1 (ITSN1) harboring one or five SH3 domains A-E, respectively. We followed diurnal variations by pull down experiments using SH3 fusion protein and brains from mice entrained in a strict 24-h light-dark cycle (12-h light Zeitgeber (ZT) 0, 6; 12-h dark ZT 12 and 18).
WebThe major isoforms are ITSN1-L and ITSN1-S. Expression for ITSN1 is ubiquitous in adult/fetal tissue, except isoform 1 which is mostly found in the brain. The most notable expression is found in muscle, spleen, skeletal muscle, testis, heart, ovary and all … allura tilesallura smooth vertical panelWebAnti-ITSN1 antibody produced in chicken, affinity isolated antibody Catalog Number GW21428 Formerly listed as GenWay Catalog Number 15-288-21428, Intersectin-1 Antibody. Storage Temperature Store at –20 °C Synonyms: Intersectin 1 (SH3 domain protein); SH3 domain protein-1A; intersectin (SH3 domain protein 1A); human allura trim colorsWebThe multidomain scaffolding protein intersectin 1 (ITSN1) is an important regulator of this process. ITSN1 stimulates ubiquitylation of the epidermal growth factor receptor (EGFR) through enhancing the activity of the Cbl E3 ubiquitin ligase. However, the precise mechanism through which ITSN1 enhances Cbl activity is unclear. allura stucco vertical panelWeb9 jan. 2024 · 阿尔茨海默病（Alzheimer's disease， AD）是最常见的中枢神经系统（central nervous system， CNS）退行性疾病，也是痴呆的最常见类型，其主要临床表现有以记忆减退为主要表现的进行性认知功能障碍及其他神经精神症状[1]，病理上以脑内 β-淀粉样 … allura trim sizeshttp://genome.cse.ucsc.edu/cgi-bin/hgGene?hgsid=1606766419_Tg8e56cADHfATHzAGHYT5aIOZJxm&hgg_section_method_close=1 allura stucco panel sidingWeb18 okt. 2007 · Intersectin-1 is an evolutionarily conserved, multidomain protein that functions in clathrin-associated endocytosis and as a mediator of MAPK signaling pathways ( Tsyba et al., 2004 ). Cloning and Expression Chen and Antonarakis (1997) used exon trapping to identify portions of genes on human chromosome 21. allura vaginal stent