Ion-682884-cs2
Web- To evaluate the effect of treatment with ION-682884 compared to placebo for 120 weeks on the composite endpoint of cardiovascular (CV) mortality. Cedars-Sinai Academics; Cedars ... ION-682884-CS2. ClinicalTrials.gov ID. NCT04136171. Key Eligibility. … WebGrup de recerca: Malalties Cardiovasculars. Servei: Cardiologia. Investigador/a principal: Rodríguez Palomares, Jose Fernando. Malaltia: Malalties del sistema circulatori. Fase: Fase III. Estat reclutament: Reclutant voluntaris. Estudio multicéntrico, aleatorizado, doble …
Ion-682884-cs2
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WebION-682884 reduces the level of TTR in the blood of animals and healthy volunteers tested to date. Reducing the amount of TTR in participants blood may reduce the amount of amyloid deposits in participants body and may keep participants cardiomyopathy from … Web39 ION-682884-CS2 IONIS Pharnaceuticals 2024-002835-27 3 A Phase 3 Global, Double-Blind, Randomized,Placebo‑Controlled Study to Evaluate the Efficacy and Safety of ION-682884 in Patients with Transthyretin‑Mediated Amyloid Cardiomyopathy (ATTR CM) PI …
Web21 okt. 2024 · Full Title of Study: “A Phase 3 Global, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of ION-682884 in Patients With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)” Study Type. Study Type: Interventional; Study Design. Allocation: Randomized; Intervention Model: Parallel … Web1 jul. 2024 · AKCEA-TTR-LRX (ION-682884) is an antisense oligonucleotide (ASO) that inhibits the production of TTR. It has a similar design and sequence as inotersen (the parent compound), ...
Web21 feb. 2024 · Sponsor Protocol Number: ION-682884-CS2. About this study. To evaluate the effectiveness of AKCEA-TTR-LRx compared to placebo for 120 weeks in patients with ATTR-CM receiving available standard of care (SoC). ... (ION‑682884 or placebo). Males … WebSatisfactory completion of Treatment Period and the End of Treatment Visit of the Index Study (ION-682884-CS2) OR diagnosis of ATTR-CM and satisfactory participation on ISIS 420915- CS101 study as judged by the Investigator and Sponsor. Investigator is willing …
Web21 jun. 2024 · 2. Coelho T, et al. Design and Rationale of the Global Phase 3 NEURO-TTRansform Study of Antisense Oligonucleotide AKCEA-TTR-LRx(ION-682884-CS3) in Hereditary Transthyretin-Mediated Amyloid Polyneuropathy. Neurol Ther. 2024 …
WebWaarom lithium‑ion? In vergelijking met conventionele batterijen laden lithium‑ionbatterijen sneller op, gaan ze langer mee en hebben ze een grotere vermogensdichtheid. Het resultaat is een lichtere batterij met een langere gebruiksduur. Als je begrijpt hoe deze batterijen werken, heb je er maximaal profijt van. ealing yellow bookWebRx (ION-682884) is a ligand-conjugated antisense drug designed for receptor-mediated uptake by hepatocytes, the primary source of circulating transthyretin (TTR). Enhanced delivery of the antisense pharmacophore is ex-pected to increase drug potency and … csppnhp-sus-tpt4-10WebIonis CARDIO-TTRansform Study (ION-682884-CS2) Booster Meeting - Meeting Protocol Register Personal Information First Name/Given Name * Last Name/Family Name * Gender * Email * Credentials DO DPM DVM LVN MD MPH NP NP-C PA PA-C PharmD PhD RN … ealing worried about a childWebION-682884 Code; ION-682884 SODIUM Code; IONIS-TTR-LRX SODIUM Code; ISIS-682884 Code; UNII Resources. Common Chemistry CAS Common Chemistry is an open community resource of the American Chemical Society for accessing chemical information. csppnhp-sus-tpt2.6-6Web1. Satisfactory completion of Treatment Period and the End of Treatment Visit of the Index Study (ION-682884-CS2) OR diagnosis of ATTR-CM and satisfactory participation on ISIS 420915- CS101 study as judged by the Investigator and Sponsor. 2. Investigator is … ealing youth councilWebif of child-bearing potential and engaged in sexual relations, agree to use 1 highly effective contraceptive method from the time of signing the informed consent form until at least 24 weeks after the last dose of Study Drug (ION-682884 or placebo). ealing your councillorsWebProtocol ION-682884-CS2: A Phase 3 Global, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of ION-682884 in Patients with Transthyretin-Mediated Amyloid Cardiomy 03/20/2024 - 03/20/2024 (Subcontract PI) Pharmaceutical Research Associates, Inc. IonisPharmaceuticals ealing youth clubs