WebDOI: 10.1016/S0040-4020(01)87643-2 Corpus ID: 92510326; Dictyoceratin-A and -B, Novel Antimicrobial Terpenoids from the Okinawan Marine Sponge sp. @article{Nakamura1986DictyoceratinAA, title={Dictyoceratin-A and -B, Novel Antimicrobial Terpenoids from the Okinawan Marine Sponge sp.}, author={Hideshi Nakamura and … WebThe marine spongean sesquiterpene phenols dictyoceratin-A (1) and -C (2) have been shown to induce hypoxia-selective growth inhibition in cultured cancer cells and exhibit in …
Exploring Bioactive Marine Natural Products and ... - Springer
WebMar 8, 2024 · Hypoxia-adapted cancer cells in tumors contribute to the pathological progression of cancer. The marine spongean sesquiterpene phenols dictyoceratin-A (1) … WebMar 28, 2024 · Two new antimicrobial sesquiterpenoids, dictyoceratin-A (3a) and -B (4a) were isolated from the Okinawan marine sponge sp. along with known compounds, furospinulosin-1 (1) and ilimaquinone (2). flinders river catchment
Target Identification of the Marine Natural Products …
WebMarine spongian sesquiterpene phenols, dictyoceratin-C and smenospondiol, display hypoxia-selective growth inhibition against cancer cells. Academia.edu uses cookies to personalize content, tailor ads and improve the user experience. By using our site, you agree to our collection of information through the use of cookies. ... WebMay 31, 2024 · Dictyoceratin-C; Agelasine D; Download chapter PDF 1 Introduction. Pathways for exploring bioactive natural products in the quest for novel drug discovery “seeds” may be broadly classified into two categories: target-specific screening and phenotypic screening. Target-specific screening identifies compounds effective for an … WebDec 16, 2015 · Abstract: Oral dictyoceratin-C (1) and A (2), hypoxia-selective growth inhibitors, showed potent in vivo antitumor effects in mice subcutaneously inoculated with sarcoma S180 cells. Structurally modified analogs were synthesized to assess the structure–activity relationship of the natural compounds 1 and 2 isolated from a marine … flinders scholarships