Chromothriptic
WebThe TGF-β signaling pathway controls cellular proliferation, growth and differentiation and regulates several functions of the connective tissue.Disruption of genes coding for components of the TGF-β signaling pathway or its interactors, such as fibrillin-1, has been shown to cause several human pathologies. WebJun 25, 2024 · ABSTRACT. Chromothripsis is a form of genome instability, whereby a presumably single catastrophic event generates extensive genomic rearrangements of …
Chromothriptic
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WebMar 19, 2014 · Background: Chromothripsis, a newly discovered type of complex genomic rearrangement, has been implicated in the evolution of several types of cancers. WebIn chromothriptic medulloblastoma, an ecosystem of cells from multiple genetic clones resisting treatment and leading to relapse highlighted the importance of multi-clone interplay. Finally, we identified a potential role for tumour microtubes in treatment resistance in chromothriptic medulloblastoma, suggesting cell network communication as a ...
WebAug 16, 2024 · Chromothripsis is a mitotic catastrophe that arises from multiple double strand breaks and incorrect re-joining of one or a few chromosomes. We report on … WebSep 27, 2024 · Chromothripsis is a localised catastrophic genome shattering event that can be used to study how the underlying genomic sequence affects this higher order structuring. Since chromothripsis tends to...
WebIn chromothriptic areas, an alternation of regions which retain heterozygosity-two copy (no loss or gain), with regions that have loss of heterozygosity- one copy (heterozygous … WebIn 2011, a new term, chromothripsis, was introduced raising great interest among researchers and soon motivating further investigations of the phenomenon. …
WebMay 1, 2024 · Besides hyperploidy, the genomic analysis of the resulting cell lines that survived the DNA damage induction and subsequent selection procedure implicates telomere attrition as a cause for the induction of chromothriptic patterns in the selected cells. 24 Conceptually, it seems interesting that a chemical-inducing genome-wide DNA …
WebSemantic Scholar profile for Z. Slámová, with 25 highly influential citations and 11 scientific research papers. blaby eye careWebJul 27, 2024 · Chromothripsis and kataegis are frequently observed in cancer and may arise from telomere crisis, a period of genome instability during tumorigenesis when depletion of the telomere reserve... daughtry 2006 album download zipWebDec 23, 2024 · We propose that chromothripsis is a primary mechanism that accelerates genomic DNA rearrangement and amplification into … blaby fencing leicesterWebAug 11, 2015 · However, our patient was actually haploinsufficient for at least 163 other genes that might also have contributed to efficient engraftment of her seminal chromothriptic HSC. 3 Therefore, we turned to murine models of WHIM (Cxcr4 +/S338X) and Cxcr4 haploinsufficiency (Cxcr4 +/o), in which none of the other 163 genes was … blaby fitness gymWebMay 14, 2024 · This chromothriptic event was linked to concordant upregulation of 96 loci that predominantly regulate cell-cycle machineries in advanced luminal tumors. Genome-editing analysis confirmed that an ERα hub localized on 20q13 coordinately regulates a subset of these loci localized on 17q23 through long-range chromosome interactions. daughtry 18 years lyricsWebChromothripsis is suggested to occur in 2–3% of cancers, but in certain tumors such as osteosarcoma, it has been observed in up to 25% of samples 9,10. Chromothripsis is … blaby fencing garden sheds leicesterChromothripsis is a mutational process by which up to thousands of clustered chromosomal rearrangements occur in a single event in localised and confined genomic regions in one or a few chromosomes, and is known to be involved in both cancer and congenital diseases. It occurs through one … See more Chromothripsis was first observed in sequencing the genome of a chronic lymphocytic leukaemia. Through paired end sequencing, 55 chromosomal rearrangements were found in the long arm of … See more • Large numbers of complex rearrangements in localised regions of single chromosomes or chromosome arms (showed by high density and clustered breakpoints) which suggests that chromosomes need to be condensed e.g. in See more One of the main characteristic features of chromothripsis is large numbers of complex rearrangements occurring in localised regions of single chromosomes. The ability to cause such confined damage suggests that chromosomes need to be condensed e.g. in See more Research in patients with chromothripsis-associated cancers may provide some information about prognosis. TP53 mutations and chromothripsis have been linked in SHH medulloblastoma patients. Poor clinical outcomes in neuroblastomas (such as those … See more The most widely accepted and straightforward model for chromothripsis is that within a single chromosome, distinct chromosomal regions become fragmented/shattered … See more Mutations in the TP53 gene can predispose a cell to chromothripsis. Through genome sequencing of a Sonic hedgehog medulloblastoma … See more Chromothripsis has been seen to cause oncogene amplification, amplification of oncogene containing regions and the loss of tumour suppressors. Chromosome segregation errors can lead to DNA damage and chromosomal aberrations such … See more blaby fire